Penicillin the medicine. Medlineplus drug information: penicillin v potassium oral. History of penicillin allergy often inaccurate - journal watch ....Postgraduate medicine: penicillin resistance in pneumococcal pneumonia. |
History of medicine :: penicillin -- encyclopaedia britannicaPenicillin the medicine. H work at St Mary's Hospital, London. His experiences during the war had shown him the importance of being able to treat infection in wounded patients, and his subsequent work at the hospital involved him in researching agents which might help fight infection. Download video (5MB) In 1922, Fleming discovered lysozyme, an enzyme found in human tears, which is capable of destroying bacteria. However, while the new discovery was effective at inhibiting the growth of harmless bacteria, it proved ineffective against those that caused disease. In 1928 Felming made an interesting observation while he was looking at a pile of neglected petri dishes which he had rediscovered in the general untidiness of his lab. The dishes had originally been been cultured with Staphylococcus bacteria (known to cause wounds to go septic) but the agar had gone mouldy. However, Fleming was surprised to notice that, in the areas around the mould, the colonies of Staphylococcus had stopped growing. It appeared that![]() |
Penicillin, the wonder drugsomething produced by the mould was inhibiting the growth of the bacteria. After further testing, Fleming was able to identify the inhibitory substance and name in penicillin. (More information...) This agar plate shows the effect Penicillium mould has on the growth of different bacteria. If you look carefully, you can see that the feint lines of bacteria in the brown agar do not grow close to the grey white mould. back to the top The medicine : mould to pill Building on Alexander Fleming's initial observations, Howard Florey and Ernst Chain took the discovery of penicillin towards the development of the drugs that we know as antibiotics. The overwhelming casualties during the Second World War led Florey and Chain to look at resurrecting Fleming's work. After much refinement they were able to develop a powdered form of penicillin. In 1941 the first human was treated. Penicillin was given to Reserve Constable Albert Alexander who was dying of blood poisoning from a small cut. The drug |
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