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Etg 'life saving computer' lesson planLife penicillin saving. Mann of the Swiss Federal Institute of Technology to develop penicillin. Ciba scientists wrote to Florey asking for a culture to transmit to their Swiss associate. Florey contacted Sir Edward Mellanby, head of the Medical Research Council, and expressed the view that "It seems highly undesirable that the Swiss should have it as this would mean that the Germans get it." Florey then went on to inform Fleming that the head of the U.K. National Culture Collection had been told not to supply cultures to foreign scientists. Florey, clearly worried that Ciba would approach Fleming, asked Fleming if he knew of anyone else who had a culture and therefore needed to be warned not to supply it to others (Florey 1941); in the event, the Germans never obtained a culture of Fleming's mold from Allied sources. German Attempts to Develop Penicillin During 1942, the directors of the Heochst Dye Works decided to investigate penicillin. At first only two people were involved, but this soon increased to th![]() |
Intute: health and life sciences - search resultsRee& x02014;although this third worker was only temporarily released from the army. At this point, the Germans knew little about the media and growth conditions required and, somewhat surprisingly, had difficulty obtaining a culture ofFleming's mold. The Allies were well aware of these attempts made by the Germans to develop penicillin and must have been heartened to learn of their lackluster approach, especially their initial failure to develop deep fermentation (Shama 2003). In this process, pioneered mainly by American scientists, the penicillin-producing mold is grown in large vats of aerated culture medium. Deep fermentation proved to be far more efficient than the earlier, British method, based on growing the mold on the surface of liquids in vast numbers of small bottles. By the end of 1943, the penicillin team at Hoechst had grown to 10, and they were making penicillin in shallow jars in what was a large laboratory, rather than a factory. In 1944, deep fermentation was in use, |
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