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reactions. Adverse reactions are not related to allergic reactions, and it is important to distinguish between the two. Persons who incorrectly report that they have had an allergic reaction may then be treated for a particular infection with a less-effective antibiotic. This can lead to antibiotic failure or resistance, which can be costly and prolong illness.When reporting past problems with antibiotics, it is important to provide as much detail as possible about the reaction. Patients who are uncertain if a past allergic reaction was truly caused by allergy should avoid the antibiotic.DIAGNOSIS & 151; In some situations, it is necessary to determine with certainty if a person is allergic to penicillin. Testing for allergy is recommended in the following situations:Persons who have a suspected penicillin (or closely related antibiotic) allergy and require penicillin to treat a life-threatening condition for which no alternate antibiotic is appropriatePatients who have frequent infections but have suspected allergies to many antibiotics, leaving few options for treatmentSkin testing & 151; Skin testing is the most reliable method to determine the risk of a serious allergic reaction in a person with a history of allergy to penicillin.Several different types of penicillin preparations are required for skin testing; most people are allergic to the penicillin break-down products, produced after the drug has been digested. These break-down products can be manufactured commercially but are not currently available in the United States. Thus, skin testing cannot be performed in t

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